The surge in popularity of THC-infused topical products has prompted critical questions about their impact on drug tests. This comprehensive article delves into the intricate science behind the absorption of THC through the skin. While these topicals are designed for localized relief, concerns arise about the possibility of THC entering the bloodstream and triggering positive drug test results. By understanding the complex interaction between cannabinoids and the skin, we aim to shed light on the mechanisms, influencing factors, and the likelihood of facing a positive drug test due to the application of THC-infused topicals.